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Gut Health Support

Mega SporeBiotic Gummies

MegaSporeBiotic™ Gummies are a 100% spore-based proprietary probiotic blend that supports a healthy gut microbiome by promoting microbial diversity, maintaining a healthy gut barrier, and supporting the immune system’s protective responses. MegaSporeBiotic™ for Kids gummies are a 100% spore-based proprietary probiotic blend that supports a healthy gut microbiome by promoting microbial diversity, maintaining a healthy gut barrier, and supporting the immune system’s protective responses. These delicious, easy-to-digest chewable gummies contain four strains of the beneficial, spore-forming Bacillus bacteria found in Microbiome Labs’ flagship spore-based probiotic supplement, MegaSporeBiotic™. These Bacillus bacterial cultures offer an easy way for the body’s gut microbiome to receive its needed daily support. Dosing instructions Ages 4+: Take 1 gummy per day, or as directed by your healthcare practitioner. Chew thoroughly before swallowing. Ages 9+: Take 1-2 gummies per day, or as directed by your healthcare practitioner. Chew thoroughly before swallowing.

Mega SporeBiotic Gummies Product Details

Berberin ES

Berberine is a plant alkaloid derived from several different plant species customarily used in Ayurveda and traditional Chinese medicine for various therapeutic applications. Modern clinical use and published in vivo, in vitro, and animal research studies demonstrate that the berberine metabolite dihydroberberine (DHB) is more bioavailable than berberine and offers enhanced support for healthy blood glucose metabolism. Although the mechanisms underlying the beneficial effects of berberine are not entirely clear, it is hypothesized that the modulation of gut microbes may be one mechanism by which berberine affects blood glucose metabolism. Results from animal and in vitro studies suggest that berberine moderates glucose and lipid metabolism through a multi-pathway mechanism, including the adenosine monophosphate–activated protein kinase (AMPK), c-Jun N-terminal kinase (JNK), and peroxisome proliferator-activated receptor (PPAR)-alpha pathways. Separate research on AMPK reports activating the AMPK pathway stimulates glucose uptake and fat oxidation while suppressing lipogenesis and gluconeogenesis. Berberine is also believed to be involved in the regulation of pancreatic beta cell function, and it has been observed to inhibit the expression of disaccharidases in the duodenum, resulting in less glucose formation from carbohydrate digestion. Increasing evidence indicates that gut microbiota are also crucial mediators that regulate berberine’s pharmacokinetic and biological effects. Berberine induces compositional alterations in gut microbiota and regulates gut microbe–dependent metabolites, factors that contribute to its biological effects on lipid and glucose metabolism. Additionally, gut microbiota reduce berberine to DHB, its intestine-absorbable form, which then oxidizes back to berberine after it has been absorbed into intestinal tissues and entered the blood. Berberine absorption across the intestinal epithelia is suggested to be compromised because of its “flat” chemical configuration. Berberine displays poor bioavailability and increased potential for GI distress at the oral doses required to improve biomarkers associated with glucose homeostasis. The structure of the DHB derivative of berberine is comparably open, making it more amenable to uptake. To further explore the absorbability of berberine and DHB, researchers investigated the mechanism of action by which AMPK is activated and if using DHB at lower doses than berberine could potentially improve the effect on adiposity and glucose metabolism in rodents fed a high-fat diet. Berberine had to be administered at a nearly 5-fold increased dose of 560 mg/kg/d to establish the same effects demonstrated by DHB at 100 mg/kg/d. The rodents treated with the substantially lower dose of DHB showed markedly reduced adiposity and improved glucose tolerance. Additionally, insulin sensitivity was increased in the DHB-treated animals. These results led researchers to suggest that the difference in effects between berberine and DHB is due to the enhanced bioavailability of DHB. The findings of this study indicate that DHB delivers the beneficial metabolic effects of berberine in a more absorbable form and at a lower dose. A small, randomized, double-blind, crossover pilot study (N = 5) investigated the absorption kinetics and compared the dosing of berberine and DHB required to achieve peak plasma concentrations. Subjects completed a 4-dose protocol of placebo, 500 mg of berberine, 200 mg of DHB, and 100 mg of DHB. Participants ingested the first 3 doses with breakfast, lunch, and dinner, followed by an overnight fast, then a standardized test meal accompanied by dose 4. Blood samples were collected at regular intervals after ingestion and analyzed for berberine, glucose, and insulin. Four doses of 100 mg and 200 mg of DHB produced significantly greater concentrations of plasma berberine across the 2-hour measurement window than a 500-mg dose of berberine or placebo. Results suggest that irrespective of dose, DHB achieves a greater area under the curve and peak berberine concentrations when compared with oral ingestion of berberine. Keystone Compounding Pharmacy’s Berberine ES contains DHB originating from berberine sourced from Berberis aristata and naturally extracted through an enzymatic process similar to that which occurs in the human gut. With a 5-fold relative increase in absorption rate, supplemental DHB at much lower doses than berberine has comparable beneficial metabolic effects. Suggested Use: 1 capsule once or twice daily, or use as directed by your healthcare professional.

Berberin ES Product Details

Fiber Lean

While a healthy diet and exercise are paramount to good health and maintaining healthy body composition, adding supplementary soluble fiber offers additional benefits. When selecting fiber, there are many aspects to review. Each fiber is unique in origin, purity, viscosity, and overall stability once ingested. In fact, even one type of fiber can vary greatly in quality. Amorphophallus konjac, a tuberous plant, is a rich source of the soluble fiber glucomannan. This fiber has an exceptional ability to absorb water and is one of the most viscous dietary fibers known. Not All Glucomannans Are Created Equal There are many aspects of glucomannan that affect end-product quality: the species of konjac used, the harvesting location, the time of harvesting, the production process, impurities (e.g., sulfites), viscosity, the response of the viscosity to different pH levels and temperatures, and hydration speed. For these reasons, finding the material with the most manufacturing and processing experience and scientific research behind it is important. Propol® A Propolmannan Shimizu Chemical Corporation is a pioneer in the world of dietary fiber and its health benefits. Using its vast knowledge—over 300 years of processing raw material (Japanese Amorphorphallus konjac species) and extracting glucomannan—it has developed Propol A propolmannan, a highly purified glucomannan. Shimizu’s unique and proprietary three-stage purification process is carried out in large-scale extraction plants and involves pulverizing the Amorphophallus tubers, collecting mannan-glucose particles, and polishing the particles in order to dislodge and extract noxious materials that adhere to them. With the use of cutting-edge technology, Propol A has been reduced to a special particle size that maximizes density while remaining in desirable viscous form. This process yields a pure, refined, high-performance Amorphophallus propolmannan that improves product solubility, stability, and overall functionality. Viscosity, Stability Through the Digestive Tract Viscosity is a physicochemical property of soluble fiber that reflects the fiber’s ability to thicken as it mixes with fluid. Viscosity is a recognized factor affecting physiological responses to soluble fiber. Propol A features an extremely high viscosity (100,000 mPa·s), which is thought to contribute to its health benefits. Furthermore, as a benefit of its unique processing, Propol A remains intact in the digestive tract—another key factor in fiber functionality. Viscosity and stability, taken together, produce a highly effective material that, once in the digestive tract, attracts water and forms a viscous gel-like substance that slows digestion, delays the emptying of food from the stomach into the small intestine, slows down the influx of carbohydrates and fats into the bloodstream, binds to bile acids, and impedes dietary fat absorption. Satiety and Weight Control Soluble fiber is known to act as a bulking agent in the stomach and intestine, which creates the signals of fullness and causes individuals to eat less. Studies suggest that glucomannan supplementation significantly reduces weight at doses of 3 g/d to 4 g/d when compared to placebo. In a randomized, double-blind, placebo-controlled study, the effects of 3 g/d of Propol (1 g 30-60 minutes prior to each meal) combined with 300 mg/d of calcium were studied. When dosing compliant and non-complaint subgroups were analyzed, the results indicated that compliant subjects experienced a significant reduction in scale weight, body fat percentage, and fat mass without a loss of fat-free mass or bone density. In another study, the mean weight loss for the glucomannan group was 5.5 lbs in eight weeks, while subjects in the placebo group gained 1.5 lbs. Glucose and Lipid Metabolism Soluble fiber slows the absorption of carbohydrates, which influences the release of insulin and the rate of fat storage. Glucomannan studies have not only demonstrated a positive impact on postprandial glucose handling and glucose metabolism but also on cholesterol metabolism. This latter effect is thought to result from the fact that soluble fiber reduces fat and cholesterol absorption and carries bile out of the intestines. When fewer bile acids are available, the body draws cholesterol from the bloodstream to make more. Healthy Bowel Function, Prebiotic Glucomannan not only allows more water to remain in the stool, thereby making waste softer, larger, and easier to pass through the intestines, but it is also an excellent prebiotic. In a placebo-controlled, randomized, parallel, double-blind, crossover trial, doses of 3 g/d and 4 g/d of glucomannan had a positive impact on intestinal habit (i.e., daily and weekly evacuations) and stool characteristics when compared to placebo. Glucomannan has also been shown to reduce mouth-to-cecum transit time compared to placebo. In other research, glucomannan improved defecation frequency, eased bowel movement, increased the fecal concentration of lactobacilli as well as the daily output of bifidobacteria, lactobacilli, and total bacteria. In addition, fermentation of glucomannan resulted in greater fecal acetate, propionate, and i-butyrate concentrations and lower fecal pH. Directions: Mix one to two scoops (1.6-3.2 g) in 8-12 oz of water or other non- alcoholic beverage and consume once per day, or mix one scoop as directed and consume 30 to 60 minutes before each of your two biggest meals, or use as directed by your healthcare professional.

Fiber Lean Product Details

SLIM BIOTIC

Clinical Applications Supports Healthy Weight Management* Promotes Gut Barrier Function* Promotes Intake of Less Calories* Supports Reduction of Body Fat Mass* SLIM BIOTIC features vegetarian, gluten- and dairy-free, patented HOWARU® Shape Bifidobacterium animalis subsp lactis B420. This probiotic strain has been proven safe, effective, and welltolerated. It has been shown to assist with healthy body composition by improving gut barrier function, supporting the reduction of body fat mass, and promoting less calorie consumption.*

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Hist Immune

Hist Immune Product Details

Key Biotic

Going beyond the threshold of traditional probiotic support, high-dose probiotics influence gut health and immunity in ways lower-dose probiotics cannot. Shown to activate over 1,700 genes involved in immune and inflammatory signaling, high-dose probiotics improve immune function, maintain a healthy gut-immune barrier, and maintain normal inflammatory balance. Each Key Biotic 100 capsule provides six proven probiotic strains chosen for their ability to survive the harsh GI environment to deliver superior results. Suggested Use: 1 capsule per day or as recommended by your health care professional.

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Optimal Omegas

Optimal Omegas provides 820 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as 50 mg of docosapentaemoic acid (DPA) per soft gel as re-esterified triglycerides, the preferred form with superior absorption. Vitamin E (as mixed tocopherols) and rosemary extract are used to ensure maximum purity and freshness.

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Probiotics Daily Support

Each Probiotic Daily Support capsule contains over 5 billion beneficial organisms, including representatives of both the lactobacillus and bifidobacterium genera, mixed in a base of prebiotic fructooligosaccharide. Qty: 60 or 120ct

Probiotics Daily Support Product Details